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生物活性玻璃广泛应用于骨修复及生物医药等领域，但生物活性玻璃的块状或粉末形式降解速率过快，限制了其作为长期支撑材料的应用。探究生物活性玻璃纤维(BGFs)的应用具有重要意义。研究Na_2O-CaO-SiO2-P_2O5生物活性玻璃的成纤工艺及其降解性能，发现该生物活性玻璃纤维在1 080～1 120℃可稳定成纤，拉伸强度为1 100 MPa,在模拟体液(SBF)中浸泡3星期后纤维拉伸强度稳定维持在600 MPa,表明纤维力学性能良好。浸泡在SBF中时生物活性玻璃纤维的微观形貌和网络结构发生变化，这是因为玻璃纤维中的网络外体氧化物解构析出，导致硅酸盐网络解聚。探究生物活性玻璃纤维在SBF中的降解机制，发现纤维浸泡在SBF中时通过溶解释放钙、磷等离子，在纤维表面矿化形成羟基磷灰石层，从而保持较为稳定的结构和形态，这可为骨组织的附着和生长提供良好的接触界面和长期支撑条件。
Abstract：Bioactive-glass is widely used in the fields of bone repair and biomedicine, etc.. Excessive degradation rate of bio-glass in block or powder form limits its application as a long-term support material. It is important to explore the application of bioactive glass fibers(BGFs). We investigated the fiber-forming preparation of Na_2O-CaO-SiO2-P_2O5 bioactive glass and its degradation properties. The bioactive-glass fibers can be stably formed in 1 080 to 1 120 ℃, with the tensile strength of 1 100 MPa, and the tensile strength maintains 600 MPa after immersing in simulated body fluid(SBF) for three weeks, indicating good mechanical performance. Micro-morphology and network structure of the bioactive glass fibers changed when immersed in SBF, because the network exosomal oxides in the glass fibers decompose and precipitate, leading to the depolymerization of silicate network. The degradation mechanism of bioactive glass fibers in SBF was studied. When the fibers are immersed in SBF, they release ions such as calcium and phosphorus through dissolution, and a hydroxyapatite layer is formed on the surface of the fibers through mineralization, thereby maintaining a relatively stable structure and morphology. This can provide a favorable interface and long-term support conditions for the attachment and growth of bone tissue.
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基本信息:
DOI：10.19886/j.cnki.dhdz.2025.0013
中图分类号:R318.08;TQ171.77
引用信息:
[1]雷文燕,丁梦钊,罗理达,等.Na_2O-CaO-SiO_2-P_2O_5生物活性玻璃纤维的制备及性能[J].东华大学学报(自然科学版),2025,51(06):192-197.DOI:10.19886/j.cnki.dhdz.2025.0013.
基金信息:
国家重点研发计划(2021YFB3701600)