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以四水钼酸铵((NH4)6Mo7O24·4H2O,98%)、聚乙二醇-4000(PEG-4000,99%)为原料制备纳米材料。该纳米材料的d带独特性质，使得钼元素的氧化物具有表面等离子共振效应，可以吸收一定波长的激光转化为热量从而实现肿瘤细胞的热消融使细胞死亡，同时，还可以在肿瘤酸性条件下产生大量高反应活性的羟基自由基(·OH),对肿瘤细胞有较大的损伤作用。为证明纳米材料的成功制备，采用透射电子显微镜(TEM)、X射线衍射仪、X射线光电子能谱、粒径分析、Zeta电位等手段对纳米材料进行表征，证明材料的成功制备并揭示材料的元素组成与结构信息。利用激光器和热电温度计对该纳米材料的体外光热性能进行评价，计算出材料的光热转换效率为36.53%。为证明材料胞内抗肿瘤效果进行了体外细胞试验，以评价该纳米材料的抗肿瘤治疗效果，结果表明材料有着较为有效的抗肿瘤效果。
Abstract：Nanomaterials were synthesized using ammonium heptamolybdate((NH4)6Mo7O24·4H2O, 98%) and polyethylene glycol(PEG-4000, 99%) as raw materials. The unique properties of the d-band in the nanomaterial enable molybdenum oxide to exhibit surface plasmon resonance effects, absorbing specific wavelengths of laser light and converting it into heat, leading to the thermal ablation of tumor cells without causing cell death.To confirm the successful preparation of the nanomaterial, various characterization techniques such as transmission electron microscopy(TEM), X-ray diffraction(XRD), X-ray photoelectron spectroscopy(XPS), particle size analysis, and Zeta potential measurements were used to reveal the material's elemental composition and structural information. To confirm the successful preparation of the nanomaterial, various characterization techniques such as transmission electron microscopy(TEM), X-ray diffraction(XRD), X-ray photoelectron spectroscopy(XPS), particle size analysis, and Zeta potential measurements were used to reveal the material's elemental composition and structural information. The photothermal performance of the nanomaterial was evaluated in vitro using a laser and a thermoelectric temperature controller, with a calculated photothermal conversion efficiency of 36.53%. In vitro cell experiments were conducted to evaluate the antitumor efficacy of the nanomaterial, demonstrating its effective antitumor activity.
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基本信息:
DOI：10.19886/j.cnki.dhdz.2024.0134
中图分类号:TB383.1;R318.08
引用信息:
[1]蒋京浩,徐健祥,朱威等.锰掺杂氧化钼纳米材料的制备与应用[J].东华大学学报(自然科学版),2025,51(02):107-115.DOI:10.19886/j.cnki.dhdz.2024.0134.
基金信息:
上海市科学技术委员会资助项目(22520710400,21WZ2501300,20DZ2254900)