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基于罗布麻叶(Apocynum venetum folium, AVF)优良的生物活性成分,采用绿色生物还原法,以罗布麻叶提取物为还原剂和稳定剂合成纳米银(AgNPs),并将其与壳聚糖/聚环氧乙烷(CS/PEO)混合,通过静电纺丝技术将共混聚合物制备功能性复合纳米纤维。测定评估纳米纤维膜生物材料特性。结果表明,FESEM显示纳米颗粒均匀地分散在纤维表面。添加罗布麻叶提取物介导合成的AgNPs改善了纳米纤维膜力学性能、表面润湿性以及紫外线阻隔性能。与不含AgNPs和添加AgNPs的纳米纤维膜相比,抗氧化试验表明制备的纳米银/壳聚糖-聚环氧乙烷(AgNPs/CS-PEO)复合纳米纤维膜表现出较优的自由基清除活性。抗菌试验表明,AgNPs/CS-PEO复合纳米纤维膜对金黄色葡萄球菌和大肠埃希菌表现出100%的抗菌活性。鉴于AgNPs/CS-PEO复合纳米纤维膜优异的特性,其有望在生物医用领域得到更广泛的应用。
Abstract：Based on the excellent bioactive components of Apocynum venetum folium(AVF), silver nanoparticles(AgNPs) were synthesized by green bioreduction method using AVF extract as a reducing and stabilizing agent, blended with chitosan/poly(ethylene oxide)(CS/PEO), and their blended polymers were prepared as functional composite nanofibers by electrostatic spinning technique. Characterization was carried out to determine and evaluate the biomaterial properties of the nanofiber membranes. The results showed that, as revealed by FESEM, the nanoparticles were uniformly dispersed on the fiber surface. The addition of AgNPs mediated synthesis by AVF extract improved the mechanical properties, surface wettability, and UV-blocking properties of the nanofibrous membranes. The prepared nanosilver/chitosan-poly(ethylene oxide)(AgNPs/CS-PEO)composite nanofibrous membranes exhibited superior free radical scavenging activity compared with AgNPs-free and AgNPs-added nanofibrous membranes. The antimicrobial experiments showed that AgNPs/CS-PEO composite nanofibrous membranes exhibited 100% antibacterial activity against Staphylococcus aureus and Escherichia coli..According to the excellent properties of AgNPs/CS-PEO composite nanofibrous membrane, it is expected to have a wide range of applications in biomedical field.
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基本信息:
DOI：10.19886/j.cnki.dhdz.2024.0413
中图分类号:TB383.2
引用信息:
[1]夏克尔·赛塔尔,祖力米热·艾尔肯,高晶,等.罗布麻叶提取物介导绿色合成AgNPs/CS-PEO复合纳米纤维膜的抗菌抗氧化性能[J].东华大学学报(自然科学版),2025,51(04):61-69.DOI:10.19886/j.cnki.dhdz.2024.0413.
基金信息:
新疆重点研发项目(2024B04004-3)