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驻极体能够长期稳定地储存空间电荷和偶极电荷，其产生的持续稳定静电场和微电流可调节皮肤微观结构，为极性药物分子提供定向传递动力，显著提升透皮渗透效率，展现出广阔的生物医用技术前景。为更好地调控水驻极熔喷非织造材料表面的带电极性，从而优化透皮促渗给药途径，采用高压超纯水对熔喷非织造材料进行喷射摩擦，通过改变干燥温度，制备单一极性水驻极熔喷非织造材料，并对驻极体电荷在溶液中的稳定性以及驻极体电场对精华成分的透皮促渗效果进行研究。研究发现正、负电性水驻极熔喷布均能促进皮肤对透明质酸钠的透皮吸收，吸收量分别提高20%和41%,是一种具有潜在应用价值的静电促渗功能面膜基布。
Abstract：Electret can stably store space charge and dipole charge for a long time. The continuous and stable electrostatic field and microcurrent generated by electret can regulate the skin microstructure and provide directional transmission power for polar drug molecules, significantly enhancing transdermal penetration efficiency, demonstrating broad prospects in biomedical technology. To better control the charged polarity on the surface of water electret meltblown nonwoven materials and optimize the transdermal drug delivery route, high-pressure ultrapure water was used to spray and rub the meltblown nonwoven materials. By changing the drying temperature, single-polarity water electret meltblown nonwoven materials were prepared, and the stability of electret charges in solution and the transdermal penetration effect of the electret field on essence components were studied. The results show that both positive and negative charged water electret meltblown fabrics can promote the transdermal absorption of sodium hyaluronate by the skin, with absorption amounts increasing by 20% and 41% respectively. This is a potential electrostatic penetration promoting functional mask base fabric.
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基本信息:
DOI：10.19886/j.cnki.dhdz.2024.0351
中图分类号:TS176
引用信息:
[1]闵雨晴,解柳艳,胡吉永,等.单一极性水驻极熔喷非织造材料的制备及其透皮促渗效果[J].东华大学学报(自然科学版),2025,51(06):212-217.DOI:10.19886/j.cnki.dhdz.2024.0351.
基金信息:
新疆生产建设兵团科技计划资助(2025AB073)